General pharmacology: pharmacokinetics – part 2. (~ 17 min)

Sort elements:

Effect of which of the following can be reduced by increasing the substrate concentration?

Noncompetitive inhibitors __________

Number 2 represents _______

Which of the following inhibitors increase Km?

Number 4 represents _______

Sort elements:

Which enzyme has higher affinity for substrate?

Sort elements:

Pick drugs that can be represented with line 1:

Km is __________

Slow acetylators have increased risk of which of the following?

Sort what efficacy and potency mean:

• The 350 mg of the drug is injected

• The drug is eliminated by first-order kinetics

• The volume of distribution is 35 L

• The half-life is 5 hours

Which of the following is a serum drug concentration after 10 hours?

• Partial pressures in the arterial blood of three inhalational general anesthetics are shown below

Which of the following is true about general anesthetic represented by curve 1?

• The red area represents plasma drug concentration over time after intravenous injection. The blue area represents plasma drug concentration over time after the administration of the same dose and drug orally.

How to calculate oral bioavailability?

Sort distribution of highly lipophilic drugs (e.g. general anesthetics) after administration:

Sort drug`s chemical properties according to their volume of distribution:

• The drug is infused and eliminated by first-order kinetics

• The half-life is 7 hours

• The rate of drug clearance is 3 L/hr

Which of the following is a volume of distribution of the drug?

• The drug is administered only once and eliminated by first-order kinetics

• The half-life is 10 hours

• The volume of distribution is 13 L

Now the serum drug concentration is 12,5% of a steady-state level. How much time passed since injection?

• the drug is injected intravenously

• a few minutes later, the concentration of the drug is 13 mg/L

• 2 hours later concentration is 10 mg/L

Which of the following will be the serum concentration of the drug in another 2 hours? Sort according to drug elimination properties:

• intravenous drug abuser injected an unknown quantity of drug 9 hours ago

• the half-life of the drug is 3 hours

• The volume of distribution is 200 L

• now the drug concentration is 0,5 mg/L

• first-order elimination

Which quantity of drug (in mg) he had injected?