General pharmacology: pharmacokinetics – part 3. (~ 17 min)

Reaction with which inhibitor has higher Vmax?

• Inulin clearance =100 mL/min

• Plasma concentration of substance = 1 mg/ml

• Reabsorption rate of substance  = 75 mg/min

Which of the following is the excretion rate of the substance?

Reversible competitive inhibitors ________

Sort cytochrome P450 inhibitors/inducers:

This represents _________

Which of the following inhibitors decrease Vmax?

The high affinity of an enzyme to a substrate is characterized by ________

Which of the following inhibitors bind to active site of the enzyme?

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The greater the Vmax, the ___________

Sort kinetics of elimination of drugs:

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Number 3 represents _______

• Clearance of the drug is 300 mL/min

• Volume of distribution is 35 L

Calculate the half-life.

• The drug is infused and eliminated by first-order kinetics

• The volume of distribution is 11 L

• The rate of drug clearance is 5 L/hr

• Repeating the second dose of the drug when 75% of the drug is eliminated will minimize the side effects

How often the drug should be administered?

• The drug is infused and eliminated by first-order kinetics

• The half-life is 5 hours

• The volume of distribution is 13 L

How much time would it require for the drug to reach 88% of the steady-state level?

Increase of substrate concentration doesn`t change the effect of ___________

Vmax is ________

Irreversible competitive inhibitors ________

• the drug is injected intravenously

• a few minutes later, the concentration of the drug is 20 mg/L

• 3 hours later concentration is 17 mg/L

• zero-order elimination

Which of the following will be the serum concentration of the drug in another 3 hours?

• Effects of experimental drug X on blood pressure is studied

• when drug X is administered alone it increases blood pressure (from 125/80 to 148/85)

• when angiotensin II is administered it increases blood pressure (from 125/80 to 160/100)

• when drug X is administered with angiotensin II blood pressure slightly increases (from 125/80 to 135/85)

Which of the following is the mechanism of action of drug X?

• drug concentration is 43 mg/ml

• after 4 hours drug concentration is 21,5

• first-order elimination

How many hours are required for the concentration of the drug to drop to 1,4 mg/ml?

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