Adrenal gland – part 4. (~ 20 min)

Blood pressure in 11β-hydroxylase deficiency is ____________

Pick possible causes of Cushing syndrome:

Which of the following reactions is catalyzed by 21-hydroxylase?

Let`s learn the diagnostic steps of Cushing syndrome:

Metyrapone test results:

• Both ACTH and 11-deoxycortisol ↓

This is a ________

Addison disease is associated with which of the following HLAs?

Virilization of female fetuses and precocious puberty are seen in:

Sort adrenal gland cortex hormones that are produced from surface to medulla:

• blood pressure is high

• K+ is low

• male fetus with ambiguous genitalia

Which of the following is a cause?

Sort elements:

Which of the following is a most common cause of congenital adrenal hyperplasia?

• Stress includes: exercise, starvation, trauma, illness, exposure to cold

Pick hormones which are released in response to stress:

Actions of ADH vs Aldosterone in collecting duct of nephron:

• elevated 24-hr urine free cortisol

• serum ACTH is high

• suppression of cortisol level on high-dose dexamethasone suppression test

Which of the following is the diagnosis?

• adolescent female presented with excessive body hair growth, acne, deepening of the voice

• blood pressure is high

• K+ is low

Which of the following is a cause?

Sort elements:

Sort

zona glomerulosa,

zona fasciculata,

zona reticularis

Cortisol _____________

Aldosterone level in 17α-hydroxylase deficiency is _________

Cortisol __________

Adrenal cortex originates from __________

Sex hormones level in 17α-hydroxylase deficiency are:

• Hypotension, fatigue, weight loss

• Hyperkalemia, metabolic acidosis

• 8 AM cortisol and plasma ACTH are measured

Sort differential diagnosis according to the results of cosyntropin (ACTH) stimulation test:

• hypotension

• fatigue

• hyperkalemia

Which of the following is a most likely cause of hyperpigmentation?

Cushing syndrome can be associated with ___________