Adrenal gland – part 3. (~ 20 min)

Sort elements:

• elevated 24-hr urine free cortisol

• serum ACTH is high

• no change of ACTH and cortisol after corticotropin-releasing hormone stimulation test

Which of the following is the diagnosis?

Let`s learn the diagnostic steps of the Cushing syndrome:

In 21-hydroxylase deficiency level of 17-hydroxyprogesterone is ________________

• hypertension

• stretch marks

• hyperglycemia

Which tests are used for screening of Cushing syndrome?

Sort adrenal gland cortex zones from surface to medulla:

Ambiguous genitalia and undescended testes in male fetuses are seen in __________

Sort elements:

Metyrapone test results:

• Both ACTH and 11-deoxycortisol ↑

This is a ________

This zone of adrenal cortex produces which of the following hormones?

• elevated 24-hr urine free cortisol

• serum ACTH is high

Which is the next step?

• female fetus has ambiguous genitalia and/or female virilization

According to additional symptoms presented below which of the following is a cause?

Pick causes of secondary hyperaldosteronism:

What is the name of the missed enzymes?

Cortisol has a permissive action on catecholamines because cortisol __________

Addison disease causes _________

What is the name of the missed enzymes?

Cortisol causes leukocytosis because of:

Sort elements:

Aldosterone level in 21-hydroxylase deficiency is:

Pick factors that activate renin-angiotensin-aldosterone system (stimulate synthesis of renin):

Which of the following lung tumors is most commonly associated with paraneoplastic Cushing syndrome?

Which of the following reactions is catalyzed by 11β-hydroxylase?

Which of the following is the mechanism of action of metyrapone?

Serum level of potassium in 11β-hydroxylase deficiency is ___________

Which of the following enzymes of epinephrine synthesis is induced by cortisol?

Sort adrenogenital syndrome types: