Adrenal gland – part 2. (~ 20 min)

Renin activity in 11β-hydroxylase deficiency is ____________

Which of the following drugs can be used for mineralocorticoid replacement therapy in primary adrenal insufficiency?

Sort diseases according to results of metyrapone test:

Lack of secondary sexual development in females is seen in:

Let`s repeat what does Cushing syndrome and Cushing disease mean:

Sort reactions and enzymes of the adrenal cortex:

Sort adrenal gland zones and hormones that stimulate each zone:

• female fetus has ambiguous genitalia and/or female virilization

• blood pressure is high

• K+ is low

Which of the following is a cause?

Which tests allows to distinguish between ectopic ACTH secretion and pituitary ACTH-secreting tumor?

Metyrapone test results:

• ↑ ACTH; ↓ 11-deoxycortisol

This is a ________

This zone of adrenal cortex produces which of the following hormones?

All patients with any congenital adrenal enzyme deficiency have:

• no suppression of cortisol level on low-dose dexamethasone suppression test

• serum ACTH is high

• raise of ACTH and cortisol after corticotropin-releasing hormone stimulation test

Which of the following is the diagnosis?

What is the name of the missed enzymes?

• Without cortisol, blood pressure decreases

• Without cortisol, fasting hypoglycemia develops

These effects can be explained by permissive action of on ________

Sort elements:

What is the name of the missed enzyme?

Cortisol can cause:

Serum level of potassium in 17α-hydroxylase deficiency is:

Let`s learn the diagnostic steps of Cushing syndrome:

Cholesterol 7α-hydroxylase is a rate‑limiting enzyme of ___________

Sex hormones level in 11β-hydroxylase deficiency are __________

Sort elements:

• clinical symptoms resembling Cushing syndrome

• no suppression of cortisol level on 1 mg overnight dexamethasone test

• serum ACTH is low

Which is the next step?

Juxtaglomerular cells begin secrete renin in response to _____